The prevalence of digestive tract defects in East China: A population-based study

The prevalence of digestive tract defects in East China: A population-based study

Fangfang Song¹, Jie Chen^1,2,3,4, Wei Cai ^1,2,3*

¹Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

²Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

³Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research,
Shanghai, China

⁴Department of Pediatric Surgery, Jiaxing Maternal and Child Health Care Hospital, Jiaxing University, Jiaxing City,
Zhejiang, China

*Corresponding Author: Wei Cai, Ph.D, MD, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665
Kongjiang Road, Shanghai 200092, China, Email: caiw204@sjtu.edu.cn

Received date: 07 February, 2021 Accepted date: 04 March, 2021 Published Date: 08 March, 2021

Citation: Song F, Chen J, Cai W(2022) The prevalence of digestive tract defects in East China: A population-based study. Sci J Pediatrics
Child Care Vol: 1, Issu: 1 (01-08).

Abstract

Introduction: The prevalence of congenital digestive tract defects among Chinese people is rarely reported. The aim of this study was to investigate the incidence of digestive tract defects in mainland China and reported the clinical outcomes of these cases. This study describes a local population-based study of registered births in Jiaxing, China from January 2015 to December 2019. Prevalence estimates (per 10,000 births) of digestive tract malformations were calculated. We used the χ2 test to compare the differences between categorical variables. In this study a total of 76 cases of digestive tract malformations were included. We calculated the following incidence rates per 10,000 births: 1.65 for esophageal atresia; 1.24 for congenital defects of gastric musculature; 2.33 for hypertrophic pyloric stenosis; 3.72 for duodenal and intestinal atresia; 2.25 for congenital malrotation of intestine; 1.45 for Hirschsprung’s disease; 4.75 for anal atresia/stricture; and 1.40 for biliary atresia. There were 31 cases (40.8%) of low birth weight (<2500g), 28 cases (36.8%) were premature births (<37 weeks), and 25 cases (32.9%) had concomitant congenital heart disease. This study estimated the incidence of digestive tract malformations, and the findings may provide a foundation for future epidemiologic studies of these congenital diseases in China. In addition, we found that roughly one third of our subjects with digestive tract defects also had concomitant congenital heart disease, suggesting a link between the two The prevalence of digestive tract defects in East China: A population-based study which may warrant further investigation. Moreover, our data will also be helpful in determining the resources needed for basic and public health research into digestive tract malformation in China.

Keywords: Digestive tract defects, incidence, China,
population-based study